Ontology highlight
ABSTRACT:
SUBMITTER: Chen CY
PROVIDER: S-EPMC7515634 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Chen Cheng-Yi CY McKinney Sean A SA Ellington Lacey R LR Gibson Matthew C MC
eLife 20200924
Two distinct mechanisms for primordial germ cell (PGC) specification are observed within Bilatera: early determination by maternal factors or late induction by zygotic cues. Here we investigate the molecular basis for PGC specification in <i>Nematostella</i>, a representative pre-bilaterian animal where PGCs arise as paired endomesodermal cell clusters during early development. We first present evidence that the putative PGCs delaminate from the endomesoderm upon feeding, migrate into the gonad ...[more]