Ontology highlight
ABSTRACT:
SUBMITTER: Cheng K
PROVIDER: S-EPMC7515722 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Cheng Kaiying K Xu Ying Y Chen Xuanyi X Lu Huizhi H He Yuan Y Wang Liangyan L Hua Yuejin Y
Nucleic acids research 20200901 17
RecJ reportedly participates in the base excision repair (BER) pathway, but structural and functional data are scarce. Herein, the Deinococcus radiodurans RecJ (drRecJ) deletion strain exhibited extreme sensitivity to hydrogen peroxide and methyl-methanesulphonate, as well as a high spontaneous mutation rate and an accumulation of unrepaired abasic sites in vivo, indicating the involvement of drRecJ in the BER pathway. The binding affinity and nuclease activity preference of drRecJ toward DNA su ...[more]