Ontology highlight
ABSTRACT:
SUBMITTER: Cahill J
PROVIDER: S-EPMC7516214 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Cahill Jesse J Ruffing Anne M AM
Frontiers in molecular biosciences 20200911
Although chemically inert, Xe and other noble gases have been shown to have functional effects on biological systems. For example, Xe is a powerful anesthetic with neuroprotective properties. Recent reports have claimed that Xe inhibits the activity of tissue plasminogen activator (tPA) and urate oxidase (UOX), indicating that the use of Xe as an anesthetic may have undesirable side effects. Here, we revisited the methods used to demonstrate Xe inhibition of UOX and tPA, testing both indirect an ...[more]