Hydroxysafflor Yellow A Exerts Anti-Inflammatory Effects Mediated by SIRT1 in Lipopolysaccharide-Induced Microglia Activation.
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ABSTRACT:
SUBMITTER: Qin X
PROVIDER: S-EPMC7517830 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
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Hydroxysafflor Yellow A Exerts Anti-Inflammatory Effects Mediated by SIRT1 in Lipopolysaccharide-Induced Microglia Activation.
Qin Xiude X Chen Juanjuan J Zhang Guowei G Li Chuanpeng C Zhu Jinqiang J Xue Hong H Li Jinfang J Guan Tianxiang T Zheng Haotao H Liu Yu Y Cai Haobin H
Frontiers in pharmacology 20200911
Abnormal microglia activation causes sever neuroinflammation, contributing to the development of many diseases, yet the mechanism remains incompletely unknown. In current study, we identified that Hydroxysafflor yellow A (HYA), a chalcone glycoside derived from <i>Carthamus tinctorius L</i> effectively attenuates LPS-induced inflammation response in primary microglia <i>via</i> regulating the expression of inflammatory genes and remodeling the polarization of microglia. We also reported the effe ...[more]
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