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Protease inhibitors, inflammatory markers, and their association with outcome in dogs with naturally occurring acute pancreatitis.


ABSTRACT: BACKGROUND:Acute pancreatitis (AP) presumably is associated with pancreatic protease activation, protease inhibitor (PI) depletion, and inflammatory mediator secretion. OBJECTIVES:Examine PIs and inflammatory mediator concentrations in dogs with AP and their association with death. ANIMALS:Thirty-one dogs diagnosed with AP based on clinical signs, ultrasonographic findings, and increased canine pancreatic lipase immunoreactivity (cPLI) and 51 healthy control dogs. METHODS:Antithrombin and ?2 -antiplasmin activity (ATA and ?2 AP, respectively) and concentrations of ?1 -proteinase inhibitor (?1 PI), ?2 -macroglobulin (?2 MG), C-reactive protein (CRP), interleukins (ILs)-2,6,8 and tumor necrosis factor-? (TNF-?) were prospectively measured. Severity of AP was assessed by clinical severity scoring systems. RESULTS:Mortality rate was 19%. Antithrombin activity was lower (P = .004) and maximal CRP, IL-6, and TNF-? concentrations higher (P?

SUBMITTER: Kuzi S 

PROVIDER: S-EPMC7517856 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Protease inhibitors, inflammatory markers, and their association with outcome in dogs with naturally occurring acute pancreatitis.

Kuzi Sharon S   Mazaki-Tovi Michal M   Suchodolski Jan S JS   Rimer Dar D   Lidbury Jonathan A JA   Steiner Joerg M JM   Buono Agostino A   Nivy Ran R   Segev Gilad G   Aroch Itamar I  

Journal of veterinary internal medicine 20200907 5


<h4>Background</h4>Acute pancreatitis (AP) presumably is associated with pancreatic protease activation, protease inhibitor (PI) depletion, and inflammatory mediator secretion.<h4>Objectives</h4>Examine PIs and inflammatory mediator concentrations in dogs with AP and their association with death.<h4>Animals</h4>Thirty-one dogs diagnosed with AP based on clinical signs, ultrasonographic findings, and increased canine pancreatic lipase immunoreactivity (cPLI) and 51 healthy control dogs.<h4>Method  ...[more]

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