Dataset Information

The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19.

ABSTRACT: To investigate the clinical value of changes in the subtypes of peripheral blood lymphocytes and levels of inflammatory cytokines in patients with COVID-19, the total numbers of lymphocytes and CD4+ lymphocytes and the ratio of CD4+/CD8+ lymphocytes were calculated and observed in different groups of patients with COVID-19. The results show that the lymphocytopenia in patients with COVID-19 was mainly manifested by decreases in the CD4+ T lymphocyte number and the CD4+/CD8+ ratio. The decreased number of CD4+ T lymphocytes and the elevated levels of TNF-? and IL-6 were correlated with the severity of COVID-19 disease.

SUBMITTER: Sun HB

PROVIDER: S-EPMC7518571 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19.

Sun Hua-Bao HB Zhang Yi-Ming YM Huang Li-Gui LG Lai Qi-Nan QN Mo Qun Q Ye Xin-Zhou XZ Wang Tao T Zhu Zhong-Zhen ZZ Lv Xiao-Lin XL Luo Yan-Ji YJ Gao Shi-Ding SD Xu Jin-Song JS Zhu Hao-Hao HH Li Ting T Wang Zhan-Ke ZK

PloS one 20200925 9

To investigate the clinical value of changes in the subtypes of peripheral blood lymphocytes and levels of inflammatory cytokines in patients with COVID-19, the total numbers of lymphocytes and CD4+ lymphocytes and the ratio of CD4+/CD8+ lymphocytes were calculated and observed in different groups of patients with COVID-19. The results show that the lymphocytopenia in patients with COVID-19 was mainly manifested by decreases in the CD4+ T lymphocyte number and the CD4+/CD8+ ratio. The decreased ...[more]

PMID: 32976531

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Project description:Background Clinical observations have shown that there is a relationship between coronavirus disease 2019 (COVID-19) and atypical lymphocytes in the peripheral blood; however, knowledge about the time course of the changes in atypical lymphocytes and the association with the clinical course of COVID-19 is limited. Objective Our purposes were to investigate the dynamics of atypical lymphocytes in COVID-19 patients and to estimate their clinical significance for diagnosis and monitoring disease course. Materials and methods We retrospectively identified 98 inpatients in a general ward at Kashiwa Municipal Hospital from May 1st, 2020, to October 31st, 2020. We extracted data on patient demographics, symptoms, comorbidities, blood test results, radiographic findings, treatment after admission and clinical course. We compared clinical findings between patients with and without atypical lymphocytes, investigated the behavior of atypical lymphocytes throughout the clinical course of COVID-19, and determined the relationships among the development of pneumonia, the use of supplemental oxygen and the presence of atypical lymphocytes. Results Patients with atypical lymphocytes had a significantly higher prevalence of pneumonia (80.4% vs. 42.6%, p < 0.0001) and the use of supplemental oxygen (25.5% vs. 4.3%, p = 0.0042). The median time to the appearance of atypical lymphocytes after disease onset was eight days, and atypical lymphocytes were observed in 16/98 (16.3%) patients at the first visit. Atypical lymphocytes appeared after the confirmation of lung infiltrates in 31/41 (75.6%) patients. Of the 13 oxygen-treated patients with atypical lymphocytes, approximately two-thirds had a stable or improved clinical course after the appearance of atypical lymphocytes. Conclusion Atypical lymphocytes frequently appeared in the peripheral blood of COVID-19 patients one week after disease onset. Patients with atypical lymphocytes were more likely to have pneumonia and to need supplemental oxygen; however, two-thirds of them showed clinical improvement after the appearance of atypical lymphocytes.

Dataset Information

The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19.

Publications

The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19.

Similar Datasets

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