Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice.
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ABSTRACT:
SUBMITTER: Degenhardt K
PROVIDER: S-EPMC7519322 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice.
Degenhardt Karoline K Wagner Jessica J Skodras Angelos A Candlish Michael M Koppelmann Anna Julia AJ Wild Katleen K Maxwell Rusheka R Rotermund Carola C von Zweydorf Felix F Gloeckner Christian Johannes CJ Davies Hannah A HA Madine Jillian J Del Turco Domenico D Feederle Regina R Lashley Tammaryn T Deller Thomas T Kahle Philipp P Hefendehl Jasmin K JK Jucker Mathias M Neher Jonas J JJ
Proceedings of the National Academy of Sciences of the United States of America 20200908 38
Medin is the most common amyloid known in humans, as it can be found in blood vessels of the upper body in virtually everybody over 50 years of age. However, it remains unknown whether deposition of Medin plays a causal role in age-related vascular dysfunction. We now report that aggregates of Medin also develop in the aorta and brain vasculature of wild-type mice in an age-dependent manner. Strikingly, genetic deficiency of the Medin precursor protein, MFG-E8, eliminates not only vascular aggre ...[more]
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