Ontology highlight
ABSTRACT:
SUBMITTER: Moidu NA
PROVIDER: S-EPMC7519367 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Moidu Nurshahirah Ashikin NA A Rahman Nisa Syakila NS Syafruddin Saiful Effendi SE Low Teck Yew TY Mohtar M Aiman MA
Heliyon 20200923 9
Anterior gradient-2 (AGR2) protein mediates the formation, breakage and isomerization of disulphide bonds during protein maturation in the endoplasmic reticulum (ER) and contributes to the homoeostasis of the secretory pathway. AGR2 promotes tumour development and metastasis and its elevated expression is almost completely restricted to malignant tumours. Interestingly, this supposedly ER-resident protein can be localised to other compartments of cancer cells and can also be secreted into the ex ...[more]