A data-driven medication score predicts 10-year mortality among aging adults.
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ABSTRACT:
SUBMITTER: Happola P
PROVIDER: S-EPMC7519677 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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A data-driven medication score predicts 10-year mortality among aging adults.
Häppölä Paavo P Havulinna Aki S AS Tasa Tõnis T Mars Nina J NJ Perola Markus M Kallela Mikko M Milani Lili L Koskinen Seppo S Salomaa Veikko V Neale Benjamin M BM Palotie Aarno A Daly Mark M Ripatti Samuli S
Scientific reports 20200925 1
Health differences among the elderly and the role of medical treatments are topical issues in aging societies. We demonstrate the use of modern statistical learning methods to develop a data-driven health measure based on 21 years of pharmacy purchase and mortality data of 12,047 aging individuals. The resulting score was validated with 33,616 individuals from two fully independent datasets and it is strongly associated with all-cause mortality (HR 1.18 per point increase in score; 95% CI 1.14-1 ...[more]
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