Dataset Information

A Variant of Leptin Gene Decreases the Risk of Gastric Cancer in Chinese Individuals: Evidence from a Case-Control Study.

ABSTRACT: Background:A host of studies have explored the potential connection between leptin (LEP) G19A polymorphism and the risk of cancers, but the relationship between gastric cancer (GC) susceptibility and LEP G19A polymorphism was not revealed before. The aim of this study was to investigate this relationship in Chinese Han population. Methods:Thus, this case-control study with 380 GC cases and 465 controls was designed to unearth the link between LEP G19A polymorphism and GC susceptibility. Genotyping was accomplished by a custom-made 48-Plex SNP scanTM kit. Relative LEP gene expression was detected by real-time reverse transcription-polymerase chain reaction. Results:LEP G19A polymorphism was shown to relate with a decreased risk of GC. Subgroup analyses uncovered significant connections in the males, nondrinkers, and those at age <60 years. G19A polymorphism was also linked with tumor size and location and pathological type of GC. Last, LEP gene expression in gastric tissues was considerably less than in control tissues. Conclusion:This study shows that G19A polymorphism of LEP gene is linked with a lower risk of GC in the tested Chinese Han individuals.

SUBMITTER: Ma R

PROVIDER: S-EPMC7519837 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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A Variant of <i>Leptin</i> Gene Decreases the Risk of Gastric Cancer in Chinese Individuals: Evidence from a Case-Control Study.

Ma Renjie R He Qi Q

Pharmacogenomics and personalized medicine 20200922

<h4>Background</h4>A host of studies have explored the potential connection between <i>leptin</i> (<i>LEP</i>) G19A polymorphism and the risk of cancers, but the relationship between gastric cancer (GC) susceptibility and <i>LEP</i> G19A polymorphism was not revealed before. The aim of this study was to investigate this relationship in Chinese Han population.<h4>Methods</h4>Thus, this case-control study with 380 GC cases and 465 controls was designed to unearth the link between <i>LEP</i> G19A p ...[more]

PMID: 33061532

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Project description:Obesity is related to an increased risk of gastric cardia cancer. However, the influences of excess body weight and serum total cholesterol on the risk of gastric high-grade dysplasia have not been fully characterized.A case-control study was conducted to explore the relationships between body mass index (BMI), serum total cholesterol level, and the risk of gastric high-grade dysplasia in Chinese adults. A total of 893 consecutive patients with gastric high-grade dysplasia (537 men and 356 women) and 902 controls (543 men and 359 women) were enrolled from January 2000 to October 2015. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated, and a multivariate analysis was conducted.After adjusting for age, alcohol consumption, smoking status, family history of gastric cancer or esophageal cancer, and serum total cholesterol level, a BMI ranging from 27.5 to 29.9 was significantly related to an increased risk of gastric high-grade dysplasia in both men (adjusted OR?=?1.87, 95% CI?=?1.24-2.81) and women (adjusted OR?=?2.72, 95% CI?=?1.44-5.16). The 2 highest BMI categories (27.5-29.9 and ?30.0) were identified as risk factors for gastric cardia high-grade dysplasia in both men (BMI?=?27.5-29.9: adjusted OR?=?1.78, 95% CI?=?1.02-3.10; BMI ? 30.0: adjusted OR?=?2.54, 95% CI?=?1.27-5.08) and women (BMI?=?27.5-29.9: adjusted OR?=?2.88, 95% CI?=?1.27-6.55; BMI ? 30.0: adjusted OR?=?2.77, 95% CI?=?1.36-5.64), whereas only a BMI ranging from 27.5 to 29.9 was a risk factor for gastric noncardia high-grade dysplasia in both men (adjusted OR?=?1.98, 95% CI?=?1.25-3.14) and women (adjusted OR?=?2.88, 95% CI?=?1.43-5.81). In addition, higher serum total cholesterol was associated with an increased risk of gastric noncardia high-grade dysplasia (adjusted OR?=?1.83, 95% CI?=?1.25-2.69) in women.Increased BMI was associated with an increased risk of gastric high-grade dysplasia in both men and women, and higher serum total cholesterol increased the risk of gastric noncardia high-grade dysplasia in women.

Dataset Information

A Variant of Leptin Gene Decreases the Risk of Gastric Cancer in Chinese Individuals: Evidence from a Case-Control Study.

Publications

A Variant of <i>Leptin</i> Gene Decreases the Risk of Gastric Cancer in Chinese Individuals: Evidence from a Case-Control Study.

Similar Datasets

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