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CD49a Regulates Cutaneous Resident Memory CD8+ T Cell Persistence and Response.


ABSTRACT: CD8+ tissue-resident memory T cells (TRM) persist at sites of previous infection, where they provide rapid local protection against pathogen challenge. CD8+ TRM expressing the ?1 chain (CD49a) of integrin VLA-1 have been identified within sites of resolved skin infection and in vitiligo lesions. We demonstrate that CD49a is expressed early following T cell activation in vivo, and TGF-? and IL-12 induce CD49a expression by CD8+ T cells in vitro. Despite this rapid expression, CD49a is not required for the generation of a primary CD8+ T cell response to cutaneous herpes simplex virus (HSV) infection, migration of CD8+ T cells across the epidermal basement membrane, or positioning of TRM within basal epidermis. Rather, CD49a supports CD8+ TRM persistence within skin, regulates epidermal CD8+ TRM dendritic extensions, and increases the frequency of IFN-?+ CD8+ TRM following local antigen challenge. Our results suggest that CD49a promotes optimal cutaneous CD8+ TRM-mediated immunity.

SUBMITTER: Bromley SK 

PROVIDER: S-EPMC7520726 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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CD49a Regulates Cutaneous Resident Memory CD8<sup>+</sup> T Cell Persistence and Response.

Bromley Shannon K SK   Akbaba Hasan H   Mani Vinidhra V   Mora-Buch Rut R   Chasse Alexandra Y AY   Sama Andrea A   Luster Andrew D AD  

Cell reports 20200901 9


CD8<sup>+</sup> tissue-resident memory T cells (T<sub>RM</sub>) persist at sites of previous infection, where they provide rapid local protection against pathogen challenge. CD8<sup>+</sup> T<sub>RM</sub> expressing the α1 chain (CD49a) of integrin VLA-1 have been identified within sites of resolved skin infection and in vitiligo lesions. We demonstrate that CD49a is expressed early following T cell activation in vivo, and TGF-β and IL-12 induce CD49a expression by CD8<sup>+</sup> T cells in vit  ...[more]

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