Ontology highlight
ABSTRACT:
SUBMITTER: Bromley SK
PROVIDER: S-EPMC7520726 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Bromley Shannon K SK Akbaba Hasan H Mani Vinidhra V Mora-Buch Rut R Chasse Alexandra Y AY Sama Andrea A Luster Andrew D AD
Cell reports 20200901 9
CD8<sup>+</sup> tissue-resident memory T cells (T<sub>RM</sub>) persist at sites of previous infection, where they provide rapid local protection against pathogen challenge. CD8<sup>+</sup> T<sub>RM</sub> expressing the α1 chain (CD49a) of integrin VLA-1 have been identified within sites of resolved skin infection and in vitiligo lesions. We demonstrate that CD49a is expressed early following T cell activation in vivo, and TGF-β and IL-12 induce CD49a expression by CD8<sup>+</sup> T cells in vit ...[more]