Ontology highlight
ABSTRACT:
SUBMITTER: Krummey SM
PROVIDER: S-EPMC7155808 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Krummey Scott M SM Morris Anna B AB Jacobs Jesica R JR McGuire Donald J DJ Ando Satomi S Tong Katherine P KP Zhang Weiwen W Robertson Jennifer J Guasch Sara A SA Araki Koichi K Larsen Christian P CP Evavold Brian D BD Kissick Haydn T HT Ford Mandy L ML
Cell reports 20200201 5
The identity of CD45 isoforms on the T cell surface changes following the activation of naive T cells and impacts intracellular signaling. In this study, we find that the anti-viral memory CD8<sup>+</sup> T pool is unexpectedly comprised of both CD45RB<sup>hi</sup> and CD45RB<sup>lo</sup> populations. Relative to CD45RB<sup>lo</sup> memory T cells, CD45RB<sup>hi</sup> memory T cells have lower affinity and display greater clonal diversity, as well as a persistent CD27<sup>hi</sup> phenotype. The ...[more]