Ontology highlight
ABSTRACT:
SUBMITTER: Tomanik M
PROVIDER: S-EPMC7520802 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20200702 14
Myrocins are a family of antiproliferative antibiotic fungal metabolites possessing a masked electrophilic cyclopropane. Preliminary chemical reactivity studies imputed the bioactivity of these natural products to a DNA cross-linking mechanism, but this hypothesis was not confirmed by studies with native DNA. We recently reported a total synthesis of (-)-myrocin G (<b>4</b>), the putative active form of the metabolite myrocin C (<b>1</b>), that featured a carefully orchestrated tandem fragment c ...[more]