Ontology highlight
ABSTRACT:
SUBMITTER: Menacho-Melgar R
PROVIDER: S-EPMC7520907 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Menacho-Melgar Romel R Decker John S JS Hennigan Jennifer N JN Lynch Michael D MD
Journal of controlled release : official journal of the Controlled Release Society 20181221
The use of biologics (peptide and protein based drugs) has increased significantly over the past few decades. However, their development has been limited by their short half-life, immunogenicity and low membrane permeability, restricting most therapies to extracellular targets and administration by injection. Lipidation is a clinically-proven post-translational modification that has shown great promise to address these issues: improving half-life, reducing immunogenicity and enabling intracellul ...[more]