Data mining: The association of 2-h postprandial plasma glucose with the fasting plasma glucose in a large Chinese population.

ABSTRACT: BACKGROUND:It is generally believed that the lower limit of postprandial plasma glucose is the same or higher than that of fasting plasma glucose (FPG). This study aimed to investigate the relationship between 2-h postprandial plasma glucose (2-hPG) and FPG. Insulin sensitivity and ?-cell function were also evaluated. METHODS:Analytical data from January 2013 to August 2018 included 10 465 participants' 2-h OGTT results and 19 518 participants' FPG and 2-hPG values after autonomous self-feeding. Participants were divided into two groups based on the relationship between FPG and 2-hPG (OGTT-A1/Postprandial-B1:FPG > 2-hPG;OGTT-A2/Postprandial-B2:FPG ? 2-hPG).Insulin sensitivity was evaluated by Matsuda index and homeostasis model assessment of insulin resistance (HOMA-IR). ?-cell function was estimated by homeostasis model assessment of ?-cell function (HOMA-?) and early-phase insulin secretion index (?I30/?G30). RESULTS:The ratio of OGTT-A1 and OGTT-A2 is 11.1%; the ratio of postprandial B1 and postprandial B2 is 13.7%. HOMA-IR and HOMA-? values were lower, while Matsuda index and ?I30/?G30 values were higher in the non-diabetic OGTT-A1 group than those in the OGTT-A2 group. The value of Matsuda index in women was 0.368 times higher than that in men in group OGTT-A1. In group OGTT-A2, the values of HOMA-IR (0.346), HOMA-? (9.096), and ?I30/?G30 (3.575) in women were lower, higher, and higher than those in men, respectively. Both HOMA-? and ?I30/?G30 decreased with age in OGTT groups. CONCLUSION:It existed that FPG was >2-hPG, and this group had better insulin sensitive and ?-cell function. The influence of age on insulin sensitivity and ?-cell function was greater than that of gender.

SUBMITTER: Sun D 

PROVIDER: S-EPMC7521326 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature