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Circulating tumor DNA: Where are we now? A mini review of the literature.

ABSTRACT: For many years tissue biopsy has been the primary procedure to establish cancer diagnosis and determine further treatment and prognosis. However, this method has multiple drawbacks, including, to mention some, being an invasive procedure carrying significant risk for fragile patients and allowing only for a "snapshot" of the tumor biology in time. The process of liquid biopsy allows for a minimally invasive procedure that provides molecular information about underlying cancer by analyzing circulating tumor DNA (ctDNA) via next-generation sequencing technology and circulating tumor cells. This paper focuses on describing the basis of ctDNA and its current utilities.

SUBMITTER: Galarza Fortuna GM

PROVIDER: S-EPMC7522544 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Circulating tumor DNA: Where are we now? A mini review of the literature.

Galarza Fortuna Gliceida Maria GM Dvir Kathrin K

World journal of clinical oncology 20200901 9

For many years tissue biopsy has been the primary procedure to establish cancer diagnosis and determine further treatment and prognosis. However, this method has multiple drawbacks, including, to mention some, being an invasive procedure carrying significant risk for fragile patients and allowing only for a "snapshot" of the tumor biology in time. The process of liquid biopsy allows for a minimally invasive procedure that provides molecular information about underlying cancer by analyzing circul ...[more]

PMID: 33033694

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