Ontology highlight
ABSTRACT:
SUBMITTER: Freudenreich JJ
PROVIDER: S-EPMC7522682 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Freudenreich Julien J JJ Bartlett Sean S Robertson Naomi S NS Kidd Sarah L SL Forrest Suzie S Sore Hannah F HF Galloway Warren R J D WRJD Welch Martin M Spring David R DR
ChemMedChem 20200612 14
The cylindrocyclophanes are a family of macrocyclic natural products reported to exhibit antibacterial activity. Little is known about the structural basis of this activity due to the challenges associated with their synthesis or isolation. We hypothesised that structural modification of the cylindrocyclophane scaffold could streamline their synthesis without significant loss of activity. Herein, we report a divergent synthesis of the cylindrocyclophane core enabling access to symmetrical macroc ...[more]