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The Biological Functions and Clinical Applications of Integrins in Cancers.

ABSTRACT: Integrins are the adhesion molecules and receptors of extracellular matrix (ECM). They mediate the interactions between cells-cells and cells-ECM. The crosstalk between cancer cells and their microenvironment triggers a variety of critical signaling cues and promotes the malignant phenotype of cancer. As a type of transmembrane protein, integrin-mediated cell adhesion is essential in regulating various biological functions of cancer cells. Recent evidence has shown that integrins present on tumor cells or tumor-associated stromal cells are involved in ECM remodeling, and as mechanotransducers sensing changes in the biophysical properties of the ECM, which contribute to cancer metastasis, stemness and drug resistance. In this review, we outline the mechanism of integrin-mediated effects on biological changes of cancers and highlight the current status of clinical treatments by targeting integrins.

SUBMITTER: Su CY

PROVIDER: S-EPMC7522798 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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The Biological Functions and Clinical Applications of Integrins in Cancers.

Su Chao-Yue CY Li Jing-Quan JQ Zhang Ling-Ling LL Wang Hui H Wang Feng-Hua FH Tao Yi-Wen YW Wang Yu-Qing YQ Guo Qiao-Ru QR Li Jia-Jun JJ Liu Yun Y Yan Yan-Yan YY Zhang Jian-Ye JY

Frontiers in pharmacology 20200911

Integrins are the adhesion molecules and receptors of extracellular matrix (ECM). They mediate the interactions between cells-cells and cells-ECM. The crosstalk between cancer cells and their microenvironment triggers a variety of critical signaling cues and promotes the malignant phenotype of cancer. As a type of transmembrane protein, integrin-mediated cell adhesion is essential in regulating various biological functions of cancer cells. Recent evidence has shown that integrins present on tumo ...[more]

PMID: 33041823

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