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Meridianin D analogues possess antibiofilm activity against Mycobacterium smegmatis.

ABSTRACT: The formation of bacterial biofilms significantly decreases the efficacy of antibiotic treatments. Herein, we've investigated the antibiofilm properties of the natural product meridianin D and a library of analogues against Mycobacterium smegmatis. As a result, we discovered several analogues that both inhibit and disperse M. smegmatis biofilms.

SUBMITTER: Brackett SM 

PROVIDER: S-EPMC7523022 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Meridianin D analogues possess antibiofilm activity against <i>Mycobacterium smegmatis</i>.

Brackett Sara M SM   Cox Karlie E KE   Barlock Samantha L SL   Huggins William M WM   Ackart David F DF   Bassaraba Randall J RJ   Melander Roberta J RJ   Melander Christian C  

RSC medicinal chemistry 20191216 1

The formation of bacterial biofilms significantly decreases the efficacy of antibiotic treatments. Herein, we've investigated the antibiofilm properties of the natural product meridianin D and a library of analogues against <i>Mycobacterium smegmatis</i>. As a result, we discovered several analogues that both inhibit and disperse <i>M. smegmatis</i> biofilms. ...[more]

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