Ontology highlight
ABSTRACT:
SUBMITTER: Zanoni M
PROVIDER: S-EPMC7523993 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Zanoni Michelle M Palesch David D Pinacchio Claudia C Statzu Maura M Tharp Gregory K GK Paiardini Mirko M Chahroudi Ann A Bosinger Steven E SE Yoon Jack J Cox Bryan B Silvestri Guido G Kulpa Deanna A DA
PLoS pathogens 20200917 9
MHC-I-restricted, virus-specific cytotoxic CD8+ T cells (CTLs) may control human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replication via the recognition and killing of productively infected CD4+ T cells. Several studies in SIV-infected macaques suggest that CD8+ T cells may also decrease virus production by suppressing viral transcription. Here, we show that non-HIV-specific, TCR-activated non-cytolytic CD8+ T cells suppress HIV transcription via a virus- and MHC-ind ...[more]