Ontology highlight
ABSTRACT:
SUBMITTER: Cavanagh SE
PROVIDER: S-EPMC7524553 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Cavanagh Sean Edward SE Lam Norman H NH Murray John D JD Hunt Laurence Tudor LT Kennerley Steven Wayne SW
eLife 20200929
Decision-making biases can be features of normal behaviour, or deficits underlying neuropsychiatric symptoms. We used behavioural psychophysics, spiking-circuit modelling and pharmacological manipulations to explore decision-making biases during evidence integration. Monkeys showed a pro-variance bias (PVB): a preference to choose options with more variable evidence. The PVB was also present in a spiking circuit model, revealing a potential neural mechanism for this behaviour. To model possible ...[more]