Vaccination with ADCC activating HA peptide epitopes provides partial protection from influenza infection.
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ABSTRACT:
SUBMITTER: Kavian N
PROVIDER: S-EPMC7524583 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Vaccination with ADCC activating HA peptide epitopes provides partial protection from influenza infection.
Kavian Niloufar N Hachim Asmaa A Poon Leo L M LLM Valkenburg Sophie A SA
Vaccine 20200725 37
Influenza-specific antibody dependent cellular cytotoxicity (ADCC) antibodies have a broad cross reactivity and potential as an immune correlate for universal vaccines. Peptide-mapping for ADCC reactivity of H1-HA and H7-HA proteins from human serum samples identified high ADCC-inducing peptides in both the HA1 and HA2 regions. Vaccination of mice with single ADCC-peptides induced ADCC activity leading to partial protection from lethal influenza challenge, with increased survival, reduced viral ...[more]
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