Dietary fatty acid intake and gut microbiota determine circulating endocannabinoidome signaling beyond the effect of body fat.
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ABSTRACT:
SUBMITTER: Castonguay-Paradis S
PROVIDER: S-EPMC7524791 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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Dietary fatty acid intake and gut microbiota determine circulating endocannabinoidome signaling beyond the effect of body fat.
Castonguay-Paradis Sophie S Lacroix Sébastien S Rochefort Gabrielle G Parent Lydiane L Perron Julie J Martin Cyril C Lamarche Benoît B Raymond Frédéric F Flamand Nicolas N Di Marzo Vincenzo V Veilleux Alain A
Scientific reports 20200929 1
The endocannabinoidome encompasses several fatty acid (FA)-derived mediators, including the endocannabinoid anandamide (AEA) and 2-arachidonoyl-glycerol (2-AG), which served as targets for anti-obesity drug development, and their congener N-acyl-ethanolamines (NAEs) and 2-monoacyl-glycerols (2‑MAGs), which are involved in food intake and energy metabolism. Body weight and fat distribution have been suggested as determinants of peripheral endocannabinoid levels. We aimed at investigating factors, ...[more]
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