Ontology highlight
ABSTRACT:
SUBMITTER: Suresh RR
PROVIDER: S-EPMC7524976 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Suresh R Rama RR Jain Shanu S Chen Zhoumou Z Tosh Dilip K DK Ma Yanling Y Podszun Maren C MC Rotman Yaron Y Salvemini Daniela D Jacobson Kenneth A KA
Purinergic signalling 20200727 3
Prodrugs (MRS7422, MRS7476) of highly selective A<sub>3</sub> adenosine receptor (AR) agonists Cl-IB-MECA and MRS5698, respectively, were synthesized by succinylation of the 2' and 3' hydroxyl groups, and the parent, active drug was shown to be readily liberated upon incubation with liver esterases. The prodrug MRS7476 had greatly increased aqueous solubility compared with parent MRS5698 and was fully efficacious and with a longer duration than MRS7422 in reversing mouse neuropathic pain (chroni ...[more]