Ontology highlight
ABSTRACT:
SUBMITTER: Heinrich ML
PROVIDER: S-EPMC7525497 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Heinrich Megan L ML Boisen Matthew L ML Nelson Diana K S DKS Bush Duane J DJ Cross Robert W RW Koval Anatoliy P AP Hoffmann Andrew R AR Beddingfield Brandon J BJ Hastie Kathryn M KM Rowland Megan M MM Aimukanova Irina I Koval Sophia S Lathigra Raju R Borisevich Viktoriya V Momoh Mambu M Sandi John Demby JD Goba Augustine A Odia Lkponmwosa L Baimba Francis F Aiyepada John O JO Ebo Benevolence B Eromon Philomena P Ugwu Chinedu C Folarin Onikepe O Olumade Testimony T Onyechi MacDonald N MN Etafo Johnson J Adeyemi Rashidat R Ella Elijah E EE Aminu Maryam M Gomerep Simji S SS Eke Matthew Afam MA Ogunsanya Olusola O Akpede George O GO Asogun Danny O DO Okogbenin Sylvanus A SA Okokhere Peter O PO Holst Johan J Shaffer Jeffrey G JG Schieffelin John S JS Geisbert Thomas W TW Saphire Erica Ollmann EO Happi Christian T CT Grant Donald S DS Garry Robert F RF Branco Luis M LM
Scientific reports 20200929 1
Lassa virus (LASV) is the causative agent of Lassa fever, an often-fatal hemorrhagic disease that is endemic in West Africa. Seven genetically distinct LASV lineages have been identified. As part of CEPI's (Coalition for Epidemic Preparedness Innovations) Lassa vaccine development program, we assessed the potential of the human immune system to mount cross-reactive and cross-protective humoral immune responses to antigens from the most prevalent LASV lineages, which are lineages II and III in Ni ...[more]