Ontology highlight
ABSTRACT:
SUBMITTER: Bilodeau P
PROVIDER: S-EPMC7525810 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Bilodeau Patricia P Jacobsen Daniel D Law-Vinh Denise D Lee Jonathan M JM
Molecular biology of the cell 20200617 17
Cell shape is regulated by cell adhesion and cytoskeletal and membrane dynamics. Cell shape, adhesion, and motility have a complex relationship and understanding them is important in understanding developmental patterning and embryogenesis. Here we show that the lipid kinase phosphatidylinositol 4-kinase III beta (PI4KIIIβ) regulates cell shape, migration, and focal adhesion (FA) number. PI4KIIIβ generates phosphatidylinositol 4-phosphate (PI4P) from phosphatidylinositol and is highly expressed ...[more]