Ontology highlight
ABSTRACT:
SUBMITTER: Mudd JC
PROVIDER: S-EPMC7526541 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Mudd Joseph C JC Lai Stephen S Shah Sanjana S Rahmberg Andrew A Flynn Jacob K JK Starke Carly E CE Perkins Molly R MR Ransier Amy A Darko Sam S Douek Daniel C DC Hirsch Vanessa M VM Cameron Mark M Brenchley Jason M JM
JCI insight 20200917 18
African green monkeys (AGMs) are natural hosts of SIV that postthymically downregulate CD4 to maintain a large population of CD4-CD8aa+ virus-resistant cells with Th functionality, which can result in AGMs becoming apparently cured of SIVagm infection. To understand the mechanisms of this process, we performed genome-wide transcriptional analysis on T cells induced to downregulate CD4 in vitro from AGMs and closely related patas monkeys and T cells that maintain CD4 expression from rhesus macaqu ...[more]