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Prostate cancer risk SNP rs10993994 is a trans-eQTL for SNHG11 mediated through MSMB.


ABSTRACT: How genome-wide association studies-identified single-nucleotide polymorphisms (SNPs) affect remote genes remains unknown. Expression quantitative trait locus (eQTL) association meta-analysis on 496 prostate tumor and 602 normal prostate samples with 117 SNPs revealed novel cis-eQTLs and trans-eQTLs. Mediation testing and colocalization analysis demonstrate that MSMB is a cis-acting mediator for SNHG11 (P?

SUBMITTER: Bicak M 

PROVIDER: S-EPMC7526792 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Prostate cancer risk SNP rs10993994 is a trans-eQTL for SNHG11 mediated through MSMB.

Bicak Mesude M   Wang Xing X   Gao Xiaoni X   Xu Xing X   Väänänen Riina-Minna RM   Taimen Pekka P   Lilja Hans H   Pettersson Kim K   Klein Robert J RJ  

Human molecular genetics 20200601 10


How genome-wide association studies-identified single-nucleotide polymorphisms (SNPs) affect remote genes remains unknown. Expression quantitative trait locus (eQTL) association meta-analysis on 496 prostate tumor and 602 normal prostate samples with 117 SNPs revealed novel cis-eQTLs and trans-eQTLs. Mediation testing and colocalization analysis demonstrate that MSMB is a cis-acting mediator for SNHG11 (P < 0.01). Removing rs10993994 in LNCaP cell lines by CRISPR/Cas9 editing shows that the C-al  ...[more]

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