Ontology highlight
ABSTRACT:
SUBMITTER: Bicak M
PROVIDER: S-EPMC7526792 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Bicak Mesude M Wang Xing X Gao Xiaoni X Xu Xing X Väänänen Riina-Minna RM Taimen Pekka P Lilja Hans H Pettersson Kim K Klein Robert J RJ
Human molecular genetics 20200601 10
How genome-wide association studies-identified single-nucleotide polymorphisms (SNPs) affect remote genes remains unknown. Expression quantitative trait locus (eQTL) association meta-analysis on 496 prostate tumor and 602 normal prostate samples with 117 SNPs revealed novel cis-eQTLs and trans-eQTLs. Mediation testing and colocalization analysis demonstrate that MSMB is a cis-acting mediator for SNHG11 (P < 0.01). Removing rs10993994 in LNCaP cell lines by CRISPR/Cas9 editing shows that the C-al ...[more]