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Climate change is likely to increase the development rate of anthelmintic resistance in equine cyathostomins in New Zealand

ABSTRACT: Climate change is likely to influence livestock production by increasing the prevalence of diseases, including parasites. The traditional practice of controlling nematodes in livestock by the application of anthelmintics is, however, increasingly compromised by the development of resistance to these drugs in parasite populations. This study used a previously developed simulation model of the entire equine cyathostomin lifecycle to investigate the effect a changing climate would have on the development of anthelmintic resistance. Climate data from six General Circulation Models based on four different Representative Concentration Pathways was available for three New Zealand locations. These projections were used to estimate the time resistance will take to develop in the middle (2040–49) and by the end (2090–99) of the century in relation to current (2006–15) conditions under two treatment scenarios of either two or six yearly whole-herd anthelmintic treatments. To facilitate comparison, a scenario without any treatments was included as a baseline. In addition, the size of the infective and parasitic stage nematode population during the third simulation year were estimated. The development of resistance varied between locations, time periods and anthelmintic treatment strategies. In general, the simulations indicated a more rapid development of resistance under future climates coinciding with an increase in the numbers of infective larvae on pasture and encysted parasitic stages. This was especially obvious when climate changes resulted in a longer period suitable for development of free-living parasite stages. A longer period suitable for larval development resulted in an increase in the average size of the parasite population with a larger contribution from eggs passed by resistant worms surviving the anthelmintic treatments. It is projected that climate change will decrease the ability to control livestock parasites by means of anthelmintic treatments and non-drug related strategies will become increasingly important for sustainable parasite control. Graphical abstract Image 1 Highlights • The development of anthelmintic resistance under climate change was simulated.• Climate can become more suitable for parasite development, increasing population size.• The time resistance took to develop was linked to changes in parasite population size.• Non-drug related strategies will become increasingly important for parasite control.

SUBMITTER: Sauermann C

PROVIDER: S-EPMC7527676 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Project description:Climate change has already been affecting the regional suitability of grapevines with significant advances in phenology being observed globally in the last few decades. This has significant implications for New Zealand, where the wine industry represents a major share of the horticultural industry revenue. We modeled key crop phenological stages to better understand temporal and spatial shifts in three important regions of New Zealand (Marlborough, Hawke's Bay, Central Otago) for three dominant cultivars (Merlot, Pinot noir, and Sauvignon blanc) and one potential new and later ripening cultivar (Grenache). Simulations show an overall advance in flowering, véraison, and sugar ripeness by mid-century with more pronounced advance by the end of the century. Results show the magnitude of changes depends on the combination of greenhouse gas emission pathway, grape cultivar, and region. By mid-century, in the Marlborough region for instance, the four cultivars would flower 3 to 7 days earlier and reach sugar ripeness 7 to 15 days earlier depending on the greenhouse gas emission pathway. For growers to maintain the same timing of key phenological stages would require shifting planting of cultivars to more Southern parts of the country or implement adaptation strategies. Results also show the compression of time between flowering and véraison for all three dominant cultivars is due to a proportionally greater advance in véraison, particularly for Merlot in the Hawke's Bay and Pinot noir in Central Otago. Cross-regional analysis also raises the likelihood of the different regional cultivars ripening within a smaller window of time, complicating harvesting schedules across the country. However, considering New Zealand primarily accommodates cool climate viticulture cultivars, our results suggest that late ripening cultivars or extended ripening window in cooler regions may be advantageous in the face of climate change. These insights can inform New Zealand winegrowers with climate change adaptation options for their cultivar choices.

Project description:Consisting of approximately 50 different species, the cyathostomin parasites are ubiquitous in grazing horses. Co-infection with several species is common, and large burdens can cause the fatal disease of larval cyathostominosis. Due to intense anthelmintic drug use, cyathostomin resistance has developed to all available anthelmintic drug groups. Resistance to the anthelmintic drug pyrantel (PYR) has been documented in over 90% of studies published over the past two decades. In Sweden, a study performed in the early 2000s only confirmed resistance in 4.5% of farms. Further, prescription-only administration of equine anthelmintic drugs was enforced in Sweden in 2007. However, it is unknown if this conservative drug use has maintained PYR efficacy in cyathostomins. The aim of the present study was to investigate the effect of PYR on cyathostomin infection in Sweden using fecal egg count reduction tests (FECRTs). Further, the effect of PYR treatment on cyathostomin species composition was studied using metabarcoding. Sixteen farms with at least six horses excreting a minimum of 100 eggs per gram feces were included. Using the current World Association for the Advancement of Veterinary Parasitology (WAAVP) guidelines, PYR resistance was demonstrated in nine of farms, with seven farms showing full susceptibility. Farms with low biosecurity measures had significantly lower efficacy of PYR treatment. The most common cyathostomin species were Cylicocyclus nassatus, Cyathostomum catinatum, Cylicostephanus longibursatus, Cys. calicatus, Cys. goldi, Cys. minutus, Coronocyclus coronatus and Cya. pateratum, accounting for 97% of all sequence reads prior to treatment. Of these, Cyc. nassatus and Cya. catinatum had the highest occurrence, accounting for 68% of all sequence reads prior to PYR treatment. Treatment did not significantly affect the species composition. The results highlight the importance of drug efficacy testing when using PYR to treat cyathostomin infection, even when selective anthelmintic treatment and thus low treatment intensity, is used on the farm.

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Climate change is likely to increase the development rate of anthelmintic resistance in equine cyathostomins in New Zealand

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