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A Pharmacokinetic Study of Methylphenidate Hydrochloride Multilayer Extended-Release Capsules (Aptensio XR®) in Preschool-Aged Children with Attention-Deficit/Hyperactivity Disorder.

ABSTRACT: OBJECTIVE:This was a single-dose, one-period, multicenter, pharmacokinetic (PK) study to evaluate the PK of methylphenidate (MPH) hydrochloride multilayer extended-release capsules (MPH-MLR) in preschool children aged 4 to?

SUBMITTER: Adjei AL 

PROVIDER: S-EPMC7529626 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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A Pharmacokinetic Study of Methylphenidate Hydrochloride Multilayer Extended-Release Capsules (Aptensio XR<sup>®</sup>) in Preschool-Aged Children with Attention-Deficit/Hyperactivity Disorder.

Adjei Akwete L AL   Chaudhary Inder I   Kollins Scott H SH   Padilla Americo A  

Paediatric drugs 20201001 5

<h4>Objective</h4>This was a single-dose, one-period, multicenter, pharmacokinetic (PK) study to evaluate the PK of methylphenidate (MPH) hydrochloride multilayer extended-release capsules (MPH-MLR) in preschool children aged 4 to < 6 years, previously diagnosed with attention-deficit/hyperactivity disorder (ADHD), and on a stable dose of MPH.<h4>Methods</h4>Preschool-aged children (N = 10) received a single oral dose of MPH-MLR (10, 15, or 20 mg) sprinkled over applesauce; a dose equivalent to  ...[more]

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