Ontology highlight
ABSTRACT:
SUBMITTER: Yang SW
PROVIDER: S-EPMC7529893 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Yang Seung Wook SW Huang Xin X Lin Wenwei W Min Jaeki J Miller Darcie J DJ Mayasundari Anand A Rodrigues Patrick P Griffith Elizabeth C EC Gee Clifford T CT Li Lei L Li Wei W Lee Richard E RE Rankovic Zoran Z Chen Taosheng T Potts Patrick Ryan PR
Nature communications 20201001 1
Testis-restricted melanoma antigen (MAGE) proteins are frequently hijacked in cancer and play a critical role in tumorigenesis. MAGEs assemble with E3 ubiquitin ligases and function as substrate adaptors that direct the ubiquitination of novel targets, including key tumor suppressors. However, how MAGEs recognize their targets is unknown and has impeded the development of MAGE-directed therapeutics. Here, we report the structural basis for substrate recognition by MAGE ubiquitin ligases. Biochem ...[more]