Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh S
PROVIDER: S-EPMC7531848 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Ghosh Swagata S Farr Laura L Singh Aditya A Leaton Laura-Ann LA Padalia Jay J Shirley Debbie-Ann DA Sullivan David D Moonah Shannon S
PLoS pathogens 20200922 9
Understanding how the protozoan protein degradation pathway is regulated could uncover new parasite biology for drug discovery. We found the COP9 signalosome (CSN) conserved in multiple pathogens such as Leishmania, Trypanosoma, Toxoplasma, and used the severe diarrhea-causing Entamoeba histolytica to study its function in medically significant protozoa. We show that CSN is an essential upstream regulator of parasite protein degradation. Genetic disruption of E. histolytica CSN by two distinct a ...[more]