Ontology highlight
ABSTRACT:
SUBMITTER: Su H
PROVIDER: S-EPMC2628451 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Su Huabo H Huang Wei W Wang Xuejun X
The international journal of biochemistry & cell biology 20080725 3
The COP9 signalosome (CSN) is an evolutionarily conserved protein complex formed by eight subunits (CSN1 through CSN8). Deneddylating cullin family proteins is considered the bona fide function of the CSN. It has been proposed that the CSN regulates the assembly and disassembly of the cullin-based ubiquitin ligases via its deneddylation activity. Here we report that down-regulation of CSN8 by RNA interference destabilized differentially other CSN subunits and reduced the amount of CSN holo-compl ...[more]