Ontology highlight
ABSTRACT:
SUBMITTER: Lam HY
PROVIDER: S-EPMC7531903 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Lam Hiu Yan HY Arumugam Surendar S Bae Han Gyu HG Wang Cheng Chun CC Jung Sangyong S St John Ashley Lauren AL Hong Wanjin W Han Weiping W Tergaonkar Vinay V
Science advances 20200731 31
ELKS1 is a protein with proposed roles in regulated exocytosis in neurons and nuclear factor κB (NF-κB) signaling in cancer cells. However, how these two potential roles come together under physiological settings remain unknown. Since both regulated exocytosis and NF-κB signaling are determinants of mast cell (MC) functions, we generated mice lacking ELKS1 in connective tissue MCs (<i>Elks1<sup>f/f</sup> Mcpt5</i>-Cre) and found that while ELKS1 is dispensable for NF-κB-mediated cytokine product ...[more]