Ontology highlight
ABSTRACT:
SUBMITTER: Rochman ND
PROVIDER: S-EPMC7532533 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Rochman Nash D ND Wolf Yuri I YI Koonin Eugene V EV
Communications biology 20201002 1
Driver mutations (DM) are the genetic impetus for most cancers. The DM are assumed to be deleterious in species evolution, being eliminated by purifying selection unless compensated by other mutations. We present deep phylogenies for 84 cancer driver genes and investigate the prevalence of 434 DM across gene-species trees. The DM are rare in species evolution, and 181 are completely absent, validating their negative fitness effect. The DM are more common in unicellular than in multicellular euka ...[more]