Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death.
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ABSTRACT:
SUBMITTER: Deng H
PROVIDER: S-EPMC7532538 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death.
Deng Hongzhang H Yang Weijing W Zhou Zijian Z Tian Rui R Lin Lisen L Ma Ying Y Song Jibin J Chen Xiaoyuan X
Nature communications 20201002 1
Immunogenic cell death (ICD) and tumour-infiltrating T lymphocytes are severely weakened by elevated reactive oxygen species (ROS) in the tumour microenvironment. It is therefore of critical importance to modulate the level of extracellular ROS for the reversal of immunosuppressive environment. Here, we present a tumour extracellular matrix (ECM) targeting ROS nanoscavenger masked by pH sensitive covalently crosslinked polyethylene glycol. The nanoscavenger anchors on the ECM to sweep away the R ...[more]
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