Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC7534900 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Chen Jing J Martindale Jennifer L JL Abdelmohsen Kotb K Kumar Gaurav G Fortina Paolo M PM Gorospe Myriam M Rostami Abdolmohamad A Yu Shiguang S
Journal of immunology (Baltimore, Md. : 1950) 20200313 8
Dysregulated Th17 cell differentiation is associated with autoimmune diseases such as multiple sclerosis, which has no curative treatment. Understanding the molecular mechanisms of regulating Th17 cell differentiation will help find a novel therapeutic target for treating Th17 cell-mediated diseases. In this study, we investigated the cell-intrinsic processes by which RNA-binding protein HuR orchestrates Th17 cell fate decisions by posttranscriptionally regulating transcription factors <i>Irf4</ ...[more]