Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD.
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ABSTRACT:
SUBMITTER: Lee G
PROVIDER: S-EPMC7536225 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD.
Lee Giljae G You Hyun Ju HJ Bajaj Jasmohan S JS Joo Sae Kyung SK Yu Junsun J Park Seoyeon S Kang Hyena H Park Jeong Hwan JH Kim Jung Ho JH Lee Dong Hyeon DH Lee Seonhwa S Kim Won W Ko GwangPyo G
Nature communications 20201005 1
Nonalcoholic fatty liver disease (NAFLD) is associated with obesity but also found in non-obese individuals. Gut microbiome profiles of 171 Asians with biopsy-proven NAFLD and 31 non-NAFLD controls are analyzed using 16S rRNA sequencing; an independent Western cohort is used for external validation. Subjects are classified into three subgroups according to histological spectra of NAFLD or fibrosis severity. Significant alterations in microbiome diversity are observed according to fibrosis severi ...[more]
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