Ontology highlight
ABSTRACT:
SUBMITTER: Jin HF
PROVIDER: S-EPMC7536350 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Jin Hui-Fang HF Wang Ju-Feng JF Shao Ming M Zhou Kailu K Ma Xiao X Lv Xian-Ping XP
Frontiers in cell and developmental biology 20200922
MicroRNAs (miRNAs) are dysregulated in the context of many cancer types, making them potentially ideal diagnostic or therapeutic targets in patients in which they are aberrantly expressed. In the present study, we found miR-7 to be downregulated in gastric cancer (GC), and we further determined its expression to be closely linked to GC sensitivity to the chemotherapeutic compound cisplatin. This effect appears to be at least partially attributable to the regulation of LDH-A, which is a miR-7 tar ...[more]