Ontology highlight
ABSTRACT:
SUBMITTER: Ma HY
PROVIDER: S-EPMC7581818 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Ma Hong-Yu HY Li Yang Y Yin Hui-Zi HZ Yin Hang H Qu Yuan-Yuan YY Xu Qing-Yong QY
Molecular therapy. Nucleic acids 20200926
Tumor necrosis factor alpha-induced protein 8 (TNFAIP8) is implicated in the tumor progression and prognosis of triple-negative breast cancer (TNBC), but the detailed regulatory mechanism of TNFAIP8 in cisplatin tolerance in TNBC has not yet been investigated. TNFAIP8 was evidently upregulated in TNBC tumor tissues and cell lines. Knocking down TNFAIP8 led to impaired proliferation and elevated apoptosis of TNBC cells upon cisplatin (DDP) treatment. Mechanistic studies revealed that TNFAIP8 repr ...[more]