Unknown

Dataset Information

0

Oncogenic driver mutations predict outcome in a cohort of head and neck squamous cell carcinoma (HNSCC) patients within a clinical trial.

ABSTRACT: 234 diagnostic formalin-fixed paraffin-embedded (FFPE) blocks from homogeneously treated patients with locally advanced head and neck squamous cell carcinoma (HNSCC) within a multicentre phase III clinical trial were characterised. The mutational spectrum was examined by next generation sequencing in the 26 most frequent oncogenic drivers in cancer and correlated with treatment response and survival. Human papillomavirus (HPV) status was measured by p16INK4a immunohistochemistry in oropharyngeal tumours. Clinicopathological features and response to treatment were measured and compared with the sequencing results. The results indicated TP53 as the most mutated gene in locally advanced HNSCC. HPV-positive oropharyngeal tumours were less mutated than HPV-negative tumours in TP53 (p?

SUBMITTER: Fernandez-Mateos J 

PROVIDER: S-EPMC7539152 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

234 diagnostic formalin-fixed paraffin-embedded (FFPE) blocks from homogeneously treated patients with locally advanced head and neck squamous cell carcinoma (HNSCC) within a multicentre phase III clinical trial were characterised. The mutational spectrum was examined by next generation sequencing in the 26 most frequent oncogenic drivers in cancer and correlated with treatment response and survival. Human papillomavirus (HPV) status was measured by p16INK4a immunohistochemistry in oropharyngeal  ...[more]

Similar Datasets

Unknown SATB1 as oncogenic driver and potential therapeutic target in head & neck squamous cell carcinoma (HNSCC).
| S-EPMC7248088 | biostudies-literature
Unknown Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC).
| S-EPMC7521680 | biostudies-literature
Unknown Differential expression profiling of head and neck squamous cell carcinoma (HNSCC).
| S-EPMC2394447 | biostudies-literature
Unknown Radiosensitization of Head and Neck Squamous Cell Carcinoma (HNSCC) by a Podophyllotoxin.
| S-EPMC6746081 | biostudies-literature
Unknown Targeting phosphoinositide 3-kinase (PI3K) in head and neck squamous cell carcinoma (HNSCC).
| S-EPMC6460806 | biostudies-literature
Unknown PIK3CA mutations in head and neck squamous cell carcinoma.
| S-EPMC1780023 | biostudies-other
Genomics miRNA expression in head and neck squamous cell carcinoma (HNSCC)
2008-09-30 | GSE11163 | GEO
Transcriptomics miRNA expression in head and neck squamous cell carcinoma (HNSCC)
2010-05-19 | E-GEOD-11163 | biostudies-arrayexpress
Unknown Rac1 as a potential therapeutic target for chemo-radioresistant head and neck squamous cell carcinomas (HNSCC).
| S-EPMC4037830 | biostudies-other
Unknown A three-lncRNA expression signature predicts survival in head and neck squamous cell carcinoma (HNSCC).
| S-EPMC6246764 | biostudies-literature