Ontology highlight
ABSTRACT:
SUBMITTER: Blasius CK
PROVIDER: S-EPMC7539954 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20200625 37
A readily activated iron alkyl precatalyst effectively catalyzes the highly enantioselective hydroboration of N-alkyl imines. Employing a chiral bis(oxazolinylmethylidene)isoindoline pincer ligand, the asymmetric reduction of various acyclic N-alkyl imines provided the corresponding α-chiral amines in excellent yields and with up to >99 % ee. The applicability of this base metal catalytic system was further demonstrated with the synthesis of the pharmaceuticals Fendiline and Tecalcet. ...[more]