Ontology highlight
ABSTRACT:
SUBMITTER: Bereczki I
PROVIDER: S-EPMC7540527 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Bereczki Ilona I Csávás Magdolna M Szűcs Zsolt Z Rőth Erzsébet E Batta Gyula G Ostorházi Eszter E Naesens Lieve L Borbás Anikó A Herczegh Pál P
ChemMedChem 20200730 17
The limited scope of antiviral drugs and increasing problem of antiviral drug resistance represent a global health threat. Glycopeptide antibiotics and their lipophilic derivatives have emerged as relevant inhibitors of diverse viruses. Herein, we describe a new strategy for the synthesis of dual hydrophobic and lipophobic derivatives of glycopeptides to produce selective antiviral agents without membrane-disrupting activity. Perfluorobutyl and perfluorooctyl moieties were attached through linke ...[more]