Ontology highlight
ABSTRACT:
SUBMITTER: Penman BS
PROVIDER: S-EPMC7544067 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Penman Bridget S BS Gandon Sylvain S
PLoS computational biology 20201008 10
The mutation responsible for Duffy negativity, which impedes Plasmodium vivax infection, has reached high frequencies in certain human populations. Conversely, mutations capable of blocking the more lethal P. falciparum have not succeeded in malarious zones. Here we present an evolutionary-epidemiological model of malaria which demonstrates that if adaptive immunity against the most virulent effects of malaria is gained rapidly by the host, mutations which prevent infection per se are unlikely t ...[more]