Ontology highlight
ABSTRACT:
SUBMITTER: Mizuno T
PROVIDER: S-EPMC7544123 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Mizuno Tomoaki T Muroi Kei K Irie Kenji K
PLoS genetics 20200928 9
Autophagy is a fundamental process responsible for degradation and recycling of intracellular contents. In the budding yeast, non-selective macroautophagy and microautophagy of the endoplasmic reticulum (ER) are caused by ER stress, the circumstance where aberrant proteins accumulate in the ER. The more recent study showed that protein aggregation in the ER initiates ER-selective macroautophagy, referred to as ER-phagy; however, the mechanisms by which ER stress induces ER-phagy have not been fu ...[more]