The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for complex human diseases.

ABSTRACT:

Background

Interest in the interplay between host genetics and the gut microbiome in complex human diseases is increasing, with prior evidence mainly being derived from animal models. In addition, the shared and distinct microbiome features among complex human diseases remain largely unclear.

Results

This analysis was based on a Chinese population with 1475 participants. We estimated the SNP-based heritability, which suggested that Desulfovibrionaceae and Odoribacter had significant heritability estimates (0.456 and 0.476, respectively). We performed a microbiome genome-wide association study to identify host genetic variants associated with the gut microbiome. We then conducted bidirectional Mendelian randomization analyses to examine the potential causal associations betwe

SUBMITTER: Xu F 

PROVIDER: S-EPMC7545574 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature