Dataset Information

Obstructive sleep apnea as a risk factor for primary open angle glaucoma and ocular hypertension in a monocentric pilot study.

ABSTRACT: BACKGROUND:Both glaucoma and obstructive sleep apnea (OSA) are widespread diseases. OSA may presumably partly cause or worsen glaucoma, although the etiopathogenesis is unclear. Here we analyze for the first time the possible association between different glaucoma phenotypes and OSA. METHODS:110 patients (47 females, 63 males; median age 64.3?years, median BMI 26.62?kg/m2) with suspected glaucoma and without any prior diagnosis of OSA were prospectively studied by one-night home sleep apnea testing (HSAT), 101 of the patients were analyzed. HSAT parameters, like apnea hypopnea index (AHI) and oxygen desaturation index as well as opthalmological parameters like intraocular pressure (IOP) and mean defect depth (MD) were collected. Moreover, HSAT results were compared across four phenotypic groups: primary open angle glaucoma (POAG), low-tension-glaucoma (LTG), ocular hypertension (OH), and controls. RESULTS:There was no strong correlation between IOP or MD and AHI. BMI, age and gender did not differ between groups. Significant differences between POAG and LTG were found for all HSAT parameters. The AHI showed the most prominent group difference (Wilcoxon-Kruskal-Wallis rank sum test was highly significant with chi2?=?22, df?=?3 p?

SUBMITTER: Bahr K

PROVIDER: S-EPMC7545869 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Obstructive sleep apnea as a risk factor for primary open angle glaucoma and ocular hypertension in a monocentric pilot study.

Bahr Katharina K Bopp Michael M Kewader Waeel W Dootz Henri H Döge Julia J Huppertz Tilman T Simon Perikles P Prokosch-Willing Verena V Matthias Christoph C Gouveris Haralampos H

Respiratory research 20201008 1

<h4>Background</h4>Both glaucoma and obstructive sleep apnea (OSA) are widespread diseases. OSA may presumably partly cause or worsen glaucoma, although the etiopathogenesis is unclear. Here we analyze for the first time the possible association between different glaucoma phenotypes and OSA.<h4>Methods</h4>110 patients (47 females, 63 males; median age 64.3 years, median BMI 26.62 kg/m<sup>2</sup>) with suspected glaucoma and without any prior diagnosis of OSA were prospectively studied by one-n ...[more]

PMID: 33032589

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Dataset Information

Obstructive sleep apnea as a risk factor for primary open angle glaucoma and ocular hypertension in a monocentric pilot study.

Publications

Obstructive sleep apnea as a risk factor for primary open angle glaucoma and ocular hypertension in a monocentric pilot study.

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