Dataset Information

Pregnancy-associated changes in cervical noncoding RNA.

ABSTRACT: Aim: To identify pregnancy-associated changes in cervical noncoding RNA (ncRNA), including miRNA and long noncoding RNA (lncRNA), and their potential effects on biologic processes. Materials & methods: We enrolled 21 pregnant women with term deliveries (?37 weeks' gestation) in a prospective cohort and collected cervical swabs before 28 weeks' gestation. We enrolled 21 nonpregnant controls. We analyzed miRNA, lncRNA and mRNA expression, applying a Bonferroni correction. Results: Five miRNA and three lncRNA were significantly differentially (>twofold change) expressed. Putative miRNA targets are enriched in genes mediating organogenesis, glucocorticoid signaling, cell adhesion and ncRNA machinery. Conclusion: Differential cervical ncRNA expression occurs in the setting of pregnancy. Gene ontology classification reveals biological pathways through which miRNA may play a biologic role in normal pregnancy physiology.

SUBMITTER: Gerson KD

PROVIDER: S-EPMC7546170 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Pregnancy-associated changes in cervical noncoding RNA.

Gerson Kristin D KD Haviland Miriam J MJ Neo Dayna D Hecht Jonathan L JL Baccarelli Andrea A AA Brennan Kasey Jm KJ Dereix Alexandra E AE Ralston Steven J SJ Hacker Michele R MR Burris Heather H HH

Epigenomics 20200601 12

Aim: To identify pregnancy-associated changes in cervical noncoding RNA (ncRNA), including miRNA and long noncoding RNA (lncRNA), and their potential effects on biologic processes. Materials & methods: We enrolled 21 pregnant women with term deliveries (≥37 weeks' gestation) in a prospective cohort and collected cervical swabs before 28 weeks' gestation. We enrolled 21 nonpregnant controls. We analyzed miRNA, lncRNA and mRNA expression, applying a Bonferroni correction. Results: ...[more]

PMID: 32808540

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Dataset Information

Pregnancy-associated changes in cervical noncoding RNA.

Publications

Pregnancy-associated changes in cervical noncoding RNA.

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