Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC7546276 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Wang Jianzhong J Schneider Benjamin K BK Xiao Hongzhi H Qiu Jicheng J Gong Xiaohui X Seo Yeon-Jung YJ Li Jing J Mochel Jonathan P JP Cao Xingyuan X
Frontiers in veterinary science 20200924
The objective of this study was to develop a non-linear mixed-effects (NLME) model to describe the disposition kinetics of vitacoxib in cats following intravenous (I.V) and oral (P.O) (single and multiple) dosing. Data from six consecutive studies with 16 healthy neutered domestic short hair cats were pooled together to build a pharmacokinetic (PK) model using NLME. Population PK parameters were estimated using the stochastic approximation expectation maximization (SAEM) algorithm implemented in ...[more]