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Exercise intensity prescription in cancer survivors: ventilatory and lactate thresholds are useful submaximal alternatives to VO2peak.

ABSTRACT: PURPOSE:Most studies with cancer survivors use percentages of peak oxygen uptake (VO2peak) for intensity prescription. Lactate or ventilatory thresholds might be useful submaximal alternatives, but this has never been investigated. Therefore, we aimed at comparing three training sessions prescribed using %VO2peak (reference), lactate thresholds, and ventilatory thresholds in terms of meeting the vigorous-intensity zone, physiological, and psychological responses. METHODS:Twenty breast (58?±?10 years) and 20 prostate cancer survivors (68?±?6 years), 3.6?±?2.4 months after primary therapy, completed a maximal cardiopulmonary exercise test and three vigorous training sessions in randomized order: 38 min of cycling at 70% VO2peak (M-VO2peak), 97% of individual anaerobic lactate threshold (M-IAT), and 67% between ventilatory thresholds 1 and 2 (M-VT). Heart rate (HR), blood lactate concentration (bLa), perceived exertion, and enjoyment were assessed. RESULTS:Cancer survivors exercised at 75?±?23, 85?±?18, and 79?±?19 W during M-VO2peak, M-IAT, and M-VT (p?>?.05). Sessions could not be completed in 3, 8, and 6 cases. Session completers showed HR of 82?±?7, 83?±?9, and 84?±?8 %HRpeak and bLa of 3.7?±?1.9, 3.9?±?0.9, and 3.9?±?1.5 mmol·l-1, which was not different between sessions (p?>?.05). However, variance in bLa was lower in M-IAT compared to M-VO2peak (p?=?.001) and to M-VT (p?=?.022). CONCLUSION:All intensity prescription methods on average met the targeted intensity zone. Metabolic response was most homogeneous when using lactate thresholds. IMPLICATIONS FOR CANCER SURVIVORS:Submaximal thresholds are at least as useful as VO2peak for intensity prescription in cancer survivors. Overall, slightly lower percentages should be chosen to improve durability of the training sessions.

SUBMITTER: Schneider J

PROVIDER: S-EPMC7546976 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Exercise intensity prescription in cancer survivors: ventilatory and lactate thresholds are useful submaximal alternatives to VO<sub>2peak</sub>.

Schneider Justine J Schlüter Kathrin K Sprave Tanja T Wiskemann Joachim J Rosenberger Friederike F

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20200316 11

<h4>Purpose</h4>Most studies with cancer survivors use percentages of peak oxygen uptake (VO<sub>2peak</sub>) for intensity prescription. Lactate or ventilatory thresholds might be useful submaximal alternatives, but this has never been investigated. Therefore, we aimed at comparing three training sessions prescribed using %VO<sub>2peak</sub> (reference), lactate thresholds, and ventilatory thresholds in terms of meeting the vigorous-intensity zone, physiological, and psychological responses.<h4 ...[more]

PMID: 32173766

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Project description:Key pointsAMP-activated protein kinase (AMPK) is considered a major regulator of skeletal muscle metabolism during exercise. However, we previously showed that, although AMPK activity increases by 8-10-fold during ∼120 min of exercise at ∼65% V̇O2peak in untrained individuals, there is no increase in these individuals after only 10 days of exercise training (longitudinal study). In a cross-sectional study, we show that there is also a lack of activation of skeletal muscle AMPK during 120 min of cycling exercise at 65% V̇O2peak in endurance-trained individuals. These findings indicate that AMPK is not an important regulator of exercise metabolism during 120 min of exercise at 65% V̇O2peak in endurance trained men. It is important that more energy is directed towards examining other potential regulators of exercise metabolism.AbstractAMP-activated protein kinase (AMPK) is considered a major regulator of skeletal muscle metabolism during exercise. Indeed, AMPK is activated during exercise and activation of AMPK by 5-aminoimidazole-4-carboxyamide-ribonucleoside (AICAR) increases skeletal muscle glucose uptake and fat oxidation. However, we have previously shown that, although AMPK activity increases by 8-10-fold during ∼120 min of exercise at ∼65% V̇O2peak in untrained individuals, there is no increase in these individuals after only 10 days of exercise training (longitudinal study). In a cross-sectional study, we examined whether there is also a lack of activation of skeletal muscle AMPK during 120 min of cycling exercise at 65% V̇O2peak in endurance-trained individuals. Eleven untrained (UT; V̇O2peak = 37.9 ± 5.6 ml.kg-1 min-1 ) and seven endurance trained (ET; V̇O2peak = 61.8 ± 2.2 ml.kg-1 min-1 ) males completed 120 min of cycling exercise at 66 ± 4% V̇O2peak (UT: 100 ± 21 W; ET: 190 ± 15 W). Muscle biopsies were obtained at rest and following 30 and 120 min of exercise. Muscle glycogen was significantly (P < 0.05) higher before exercise in ET and decreased similarly during exercise in the ET and UT individuals. Exercise significantly increased calculated skeletal muscle free AMP content and more so in the UT individuals. Exercise significantly (P < 0.05) increased skeletal muscle AMPK α2 activity (4-fold), AMPK αThr172 phosphorylation (2-fold) and ACCβ Ser222 phosphorylation (2-fold) in the UT individuals but not in the ET individuals. These findings indicate that AMPK is not an important regulator of exercise metabolism during 120 min of exercise at 65% V̇O2peak in endurance trained men.

Project description:Psychological variables such as motivation, self-efficacy, and anxiety have been widely studied in marathon runners, usually within the framework of Bandura's theory of self-efficacy. It is also assumed a link between self-perceived fitness and physiological performance parameters such as speed at ventilatory thresholds and running economy. The purpose of this paper is to describe longitudinal trends of self-perceptions and examine their link to physiological performance parameters over time. Sixteen healthy recreational marathoners (8 males and 8 females), aged M = 37.6 (SD = 3.9) who were about to participate in a major marathon agreed to participate. After 3 months of regular training and competition in shorter distances, all participants trained during a 16-week macrocycle under the supervision of the same coaching staff. At 4-week intervals, the participants responded five times the Podium questionnaire, measuring self-perceived psychological state relative to the upcoming race, and performed five exercise performance parameters tests. Linear mixed-effects models were used to analyze the trends and associations. In general, Podium questionnaire scores were within the standard range, with the lowest values at the beginning and the highest values closer to race day. Although only perceived fitness (p < 0.001, Cohen's f 2 = 1.19) and somatic anxiety (p < 0.001, f 2 = 0.32) showed large effect sizes for the whole longitudinal period, other partial increases were found between time points. All physiological performance parameters presented significant improvements over time (Aerobic Threshold speed, p < 0.001, f 2 = 1.04; Anaerobic Threshold speed, p < 0.001, f 2 = 0.498; Running Economy in VO2, p < 0.001, f 2 = 0.349; Running Economy in energy, p = 0.024, f 2 = 0.197). The analysis of changes between consecutive time points revealed that improving perceived physical condition predicted improving self-efficacy (p < 0.001, f 2 = 1.33), and improvements in motivation were predicted by improvements in either self-efficacy (p < 0.001, f 2 = 0.36) or perceived physical condition (p = 0.003, f 2 = 0.17). Improvements in perceived fitness, self-efficacy and motivation were associated with small effect-size improvements (decreases) in anxiety. None of the physiological performance parameters was shown to predict changes in psychological variables, although their general trends over time correlated. The results have practical implications for sport psychologists and running coaches, supporting the need for integrated working.

Dataset Information

Exercise intensity prescription in cancer survivors: ventilatory and lactate thresholds are useful submaximal alternatives to VO2peak.

Publications

Exercise intensity prescription in cancer survivors: ventilatory and lactate thresholds are useful submaximal alternatives to VO<sub>2peak</sub>.

Similar Datasets

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